e-mail : chulee.y@chula.ac.th
Phone : 662 218 7163

Education

1985 B.Sc. (Medical Technology), Chiangmai University, Chiangmai, Thailand
1988 M.Sc. (Microbiology), Mahidol University, Bangkok, Thailand
1996 Ph.D. (Biotechnology), Osaka University, Osaka, Japan

Training

2000-2003 Post-doctoral fellow
Department of Cancer Genetics, Roswell Park Cancer Institute, Buffalo, New York USA
1999  The Thirteenth course “Modern Methods in Biotechnology” by International Training Programme in Biotechnology at German Research Center for Biotechnology, Braunschweig, Germany

Research Interest

– Yeast molecular biotechnology
– Development of high throughput yeast-based assay
– Bioactive compounds from natural resources
– Molecular mechanisms of the interested bioactive compounds

Publications

From Research gate Click

Selected Publications

  1. Sangkaew A, Kojornna T, Tanahashi R, Takagi H, Yompakdee C. 2021. A novel yeast-based screening system for potential compounds that can alleviate human α-synuclein toxicity. J Appl Microbiol 00: 1-13.  doi: 10.1111/jam.15256
  2. Sangkaew O, Phaonakrop N, Roytrakul S, Yompakdee C. 2020. Metaproteomic investigation of functional insight into special defined microbial starter on production of fermented rice with melanogenesis inhibition activity. PLoS ONE 15(11): e0241819. https://doi.org/10.1371/journal.pone.0241819.
  3. Sangkaew O, Yompakdee C. 2020. Fermented unpolished black rice (Oryza sativa L.) inhibits melanogenesis via Erk, p38, Akt phosphorylation in B16F10 melanoma cells. J Microbiol Biotechnol 30(8),1184-1194. doi: 10.4014/jmb.2003.03019.
  4. Sopanaporn J, Suksawatamnuay S, Sardikin A, Lengwittaya R, Chavasiri W, Miyakawa T, Yompakdee C. 2020. Pinostrobin suppresses the Ca2+-signal-dependent growth arrest in yeast by inhibiting the Swe1-mediated G2cell-cycle regulation. FEMS Yeast Res 20(4), foaa026. https://academic.oup.com/femsyr/article/20/4/. foaa026/5836717. 
  5. Sangkaew A, Samritsakulchai N, Sanachai K, Rungrotmongkol T, Chavasiri W, Yompakdee C. 2020. Two Flavonoid-based compounds from murraya paniculata as novel human carbonic anhydrase isozyme II inhibitors detected by a resazurin yeast-based assay. J Microbiol Biotechnol 30(4):552-560.
  6. Chaichompoo W, Chokchaisiri R, Sangkaew A, Pabuprapap W, Yompakdee C and Suksamrarn A. 2020. Alkaloids with anti-human carbonic anhydrase isozyme II activity from the bulbs of Crinum asiaticum L. var. asiaticum. Phytochem Lett 37,101-105.
  7. Sangkaew A, Krungkrai J, Yompakdee C. 2018. Development of a high throughput yeast-based screening assay for human carbonic anhydrase isozyme II inhibitors. AMB Express 8:124. https://doi.org/10.1186/s13568-018-0653-9
  8. Suauam P, Yingyongnarongkul B, Palaga T, Miyakawa T, Yompakdee C. 2015. Clausmarin A, Potential Immunosuppressant Revealed by Yeast-Based Assay and Interleukin-2 Production Assay in Jurkat T Cells. PLOS One DOI: 10.1371/journal.pone.0136804
  9. LuangkhlayphoA, PattaragulwanitK,LeepipatpiboonN, Yompakdee C. 2014. Development of a defined starter culture mixture for the fermentation of Sato, Thai rice based-alcoholic beverage. Science Asia 40(2):125-134. DOI: 10.2306/scienceasia1513-1874.2014.40.125
  10. BoonkerdS, YompakdeeC, MiyakawaT, ChawasiriW. 2013. A flavonoid, 5-hydroxy-3,7-dimethoxyflavone, from Kaempferiaparviflora Wall. Ex. Baker as an inhibitor of the Ca2+signal-mediated cell-cycle regulation in yeast. Ann MicrobiolDOI: 10.1007/s13213-013-0742-6.
  11. Taechavasonyoo A, ThaniyavarnJ, Yompakdee C. 2013. Identification of the molds and yeasts characteristic of a superior Loogpang,starter of Thai rice-based alcoholic beverageSato. As J Food Ag-Ind.6(01):24-38.
  12. Yompakdee C, Thunyaharn S, Phaechamud T. 2012. Bactericidal activity of methanol extracts of crabapple mangrove tree (Sonneratiacaseolaris Linn.) against multi-drug resistant pathogens.  Indian J. Pharm. Sci. 74 (3): 230-236.
  13. Tangjitjaroenkun J, Chavasiri W, Thunyaharn S, Yompakdee C. 2012. Bactericidal effects and time-kill studies of the essential oil from the fruits of Zanthoxylumlimonella on multi-drug resistant bacteria. J Essent Oil Res. 24(4): 363–370.
  14. Boonkerd, S., Yompakdee, C., Miyakawa, T. and Chavasiri, W. 2011. Screening of Thai medicinal plants for inhibitor of Ca2+signaling using a yeast cell growth-based assay. RJPBCS. 2(2): 549-557.
  15. Wangkangwan W, Boonkerd S, Chavasiri W, Sukapirom K, Pattanapanyasat K, Kongkathip N, Miyakawa T, Yompakdee C. 2009. Pinostrobin from Boesenbergiapandurata is an inhibitor of Ca2+-signal-mediated cell-cycle regulation in the yeast Saccharomyces cerevisiae. Biosci Biotechnol Biochem. 73 (7): 1679-82. Epub 2009 Jul 7. PubMed PMID: 19584530.
  16. Mickle KL, Ramanathan S, Rosebrock A, Oliva A, Chaudari A, Yompakdee C, Scott D, Leatherwood J and Huberman JA. 2007. Checkpoint independence of most DNA replication origins in fission yeast. BMC Molecular Biology. 8:112 doi:10.1186/1471-2199-8-112.
  17. Trinetra N, Thaniyavarn J, Yompakdee C, Leepipatpiboon N. The effect of different rice strains on the fravor of Sato. 31st Congress on Science and Technology of Thailand at Suranaree University of Technology, 18 – 20 October 2005
  18. Yompakdee C and Huberman JA. 2004. Enforcement of Late Replication Origin Firing by Clusters of Short G-rich DNA Sequences. J Biol Chem. 279 (40): 42337-42344.
  19. Yompakdee C, Ogawa N, Harashima S, Oshima Y. 1996. A putative membrane protein, Pho88p, involved in inorganic phosphate transport in Saccharomyces cerevisiae.  Mol Gen Genet. 251 : 580-590.
  20. Yompakdee C, Bun-ya M, Shikata K, Ogawa N, Harashima S, Oshima Y. 1996. A putative new membrane protein, Pho86p, in the inorganic phosphate uptake system of Saccharomyces cerevisiae. Gene 171: 41-47.
  21. Bun-ya M, Shikata K, Nakade S, Yompakdee C, Harashima S, Oshima Y. 1996. Two new genes, PHO86 and PHO87, involved in inorganic phosphate uptake in Saccharomyces cerevisiae. Genet. 29 : 344-351.
  22. Ogawa N, Noguchi K, Sawai H, Yamashita Y, Yompakdee C, Oshima Y. 1995. Functional domains of Pho81p, an inhibitor of Pho85p protein kinase, in the transduction pathway of Pi signals in Saccharomyces cerevisiae. Mol Cell Biol. 15: 997-1004.
  23. Masathien (Yompakdee) C, Billings P, Ratananbanangkoon . 1994. Production and characterization of monoclonal antibodies neutralizing the postsynaptic neurotoxin 3 From NajaKaouthia Venom. J Natural Toxins., 3(2) : 155-163.

Grants, Awards and Recognition